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蔡昆霖 老師

最後更新日期 : 2026-09-07


開授課程 學歷 經歷 專長及
研究領域
榮譽
及獎勵
著作 研究計畫 指導學生情況 參與國際會議 教學與研究國際交流

 

蔡昆霖  教師姓名

蔡昆霖 老師

職稱

教授

最高學歷 國立陽明大學臨床醫學研究所 2013
專長領域

心血管生理

聯絡方式 06-2353535 ext. 6219
FAX: 06-2370411
E-mail: kunlingtsai@gmail.com
  主持實驗室

心血管研究中心

 

開授課程
學年第一學期 學年第二學期
臨床導向心肺物理治療技術學 心肺物理治療學與實習
臨床藥物學 病態生理學討論
心肺物理治療學及實習 生物醫學與運動生理研究方法
高階心肺物理治療實作 運動生理學
高階心肺物理治療臨床技巧及論證 運動處方
臨床進階心肺物理治療評估 物理因子治療學
病態生理學討論  
學歷
  • 國立陽明大學臨床醫學博士 (2009-2013)   
  • 中國醫藥大學臨床醫學碩士 (2007-2009)  
  • 義守大學物理治療學士 (2003-2007)
經歷
  • 2018.10~至今 社團法人臺灣物理治療學會副祕書長
  • 2013.11~ 2014.07   台北榮民總醫院復健醫學部博士後研究員
  • 2013.08~至今   Elsevier台灣醫學期刊翻譯
  • 2009-2011   台北天母永安診所物理治療師
專長及研究領域
  •  心血管生理
  •  心肺物理治療
  •  運動生理

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榮譽及獎勵 (至少五年內)
  • 2015優秀論文獎

  • 2016優秀論文獎

  • 2018台灣藥理學會-杜聰明博士年輕學者獎

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著作 (至少五年內)
A. Journal Papers
  1. Ma CH, Wu CH, Jou IM, Tu YK, Hung CH, Chou WC, Chang YC, Hsieh PL, Tsai KL*. (2019, Sep). PKR Promotes Oxidative Stress and Apoptosis of Human Articular Chondrocytes by Causing Mitochondrial Dysfunction through p38 MAPK Activation-PKR Activation Causes Apoptosis in Human Chondrocytes.. Antioxidants (Basel), Sep 3;8(9). (SCI) 108
  2. Yen CJ, Hung CH, Kao CL, Tsai WM, Chan SH, Cheng HC, Jheng WT, Lu YJ, Tsai KL*. (2019, Dec). Multimodal exercise ameliorates exercise responses and body composition in head and neck cancer patients receiving chemotherapy. Support Care Cancer, 27(12):4687-4695. (SCI) 108
  3. Yang, H. L., Hung, C. H., Chung, W. P., & Tsai, K. L*. (2019, Dec). Effect of Exercise Intervention on Cardiac Function and Exercise Capacity in Breast Cancer Patients Receiving Chemotherapy. 物理治療, 44(4), 282-283. xSCI 108
  4. Lin, H. C., Chiang, L. L., Ong, J. H., Tsai, K. L., Hung, C. H., & Lin, C. Y. (2020, 21 May). The effects of threshold inspiratory muscle training in patients with obstructive sleep apnea: a randomized experimental study. Sleep and Breathing, 24(1), 201-209. (SCI) 108
  5. Lin, H. C., Su, C. L., Ong, J. H., Tsai, K. L., Chen, Y. W., Lin, C. Y., Chiang, L. L., & Hung, C. H. (2020, 01 Jul). Pulse Oximetry Monitor Feasible for Early Screening of Obstructive Sleep Apnea (OSA). Journal of Medical and Biological Engineering, 40(1), 62-70. (SCIE) 108
  6. Lin, Y. S., Tsai, K. L., Chen, J. N., & Wu, C. S. (2020, 18 May). Mangiferin inhibits lipopolysaccharide-induced epithelial-mesenchymal transition (EMT) and enhances the expression of tumor suppressor gene PER1 in non-small cell lung cancer cells. Environmental Toxicology, 35(10), 1070-1081. (SCI) 108
  7. Tsai, K. L., Hsieh, P. L., Chou, W. C., Hung, C. H., Yang, H. L., Chang, Y. C., Chu, P. M., Chang, M. S., & Chan, S. H. (2020, 21 Jan). IL-20 promotes hypoxia/reoxygenation-induced mitochondrial dysfunction and apoptosis in cardiomyocytes by upregulating oxidative stress by activating the PKC/NADPH oxidase pathway. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1866(5), 文章 165684. (SCI) 108
  8. Yang, H. L., Hsieh, P. L., Hung, C. H., Cheng, H. C., Chou, W. C., Chu, P. M., Chang, Y. C., & Tsai, K. L*. (2020, 28 Apr). Early moderate intensity aerobic exercise intervention prevents doxorubicin-caused cardiac dysfunction through inhibition of cardiac fibrosis and inflammation. Cancers, 12(5), 文章 1102. (SCI) 108
  9. Chuang, H. C., Tsai, K. L*., Tsai, K. J., Tu, T. Y., Shyong, Y. J., Jou, I. M., Hsu, C. C., Shih, S. S., Liu, Y. F., & Lin, C. L. (2020, 20 Nov). Oxidative stress mediates age-related hypertrophy of ligamentum flavum by inducing inflammation, fibrosis, and apoptosis through activating Akt and MAPK pathways. Aging, 12(23), 24168-24183. (SCI) 109
  10. Wang, C. Y., Hsiao, C. Y., Tsai, K. L., & Cheng, Y. H. (2020, 07 Aug). Injectable thermosensitive chitosan-based hydrogel containing ferulic acid for treating peripheral arterial disease. Journal of Tissue Engineering and Regenerative Medicine, 14(10), 1438-1448. (SCI) 109
  11. Wang, C. C., Wang, C. T., Chou, W. C., Kao, C. L., & Tsai, K. L*. (2020, 30 Oct). Hyaluronic acid injection reduces inflammatory and apoptotic markers through modulation of AKT by repressing the oxidative status of neutrophils from osteoarthritic synovial fluid. International Journal of Biological Macromolecules, 165, 2765-2772. (SCI) 109
  12. Yen, C. J., Hung, C. H., Tsai, W. M., Cheng, H. C., Yang, H. L., Lu, Y. J., & Tsai, K. L*. (2020, 18 Aug). Effect of Exercise Training on Exercise Tolerance and Level of Oxidative Stress for Head and Neck Cancer Patients Following Chemotherapy. Frontiers in Oncology, 10, 文章 1536. (SCI) 109
  13. Ma, C. H., Chiu, Y. C., Wu, C. H., Tsai, K. L., Wen, T. K., & Tu, Y. K. (2021, 01 Jun). Ipsilateral vascularised fibula with external locking plate for treatment of massive tibial bone defects. Injury, 52(6), 1629-1634. (SCI) 109
  14. Lin, K. Y., Cheng, H. C., Yen, C. J., Hung, C. H., Haung, Y. T., Yang, H. L., Cheng, W. T., & Tsai, K. L*. (2021, 01 Feb). Effects of exercise in patients undergoing chemotherapy for head and neck cancer: A pilot randomized controlled trial. International journal of environmental research and public health, 18(3), 1-14. 文章 1291. (SCIE) 109
  15. Wang, C. C., Wang, C. T., Tsai, K. L., Chou, C. L., Chao, J. K., Huang, H. Y., & Kao, C. L. (2021, 26 Jan). Effect of ultrasound-detected synovitis on therapeutic efficacy of hyaluronic acid injection for symptomatic knee osteoarthritis. Rheumatology (United Kingdom), 60(10), 4486-4494. (SCi) 109
  16. Tsai, K. L., Hsieh, P. L., Chou, W. C., Cheng, H. C., Huang, Y. T., & Chan, S. H. (2021, 26 Feb). Dapagliflozin attenuates hypoxia/reoxygenation-caused cardiac dysfunction and oxidative damage through modulation of AMPK. Cell and Bioscience, 11(1), 文章 44. (SCI) 109
  17. Tsai, K. L*., Chou, W. C., Cheng, H. C., Huang, Y. T., Chang, M. S., & Chan, S. H. (2021, 10 Feb). Anti-il-20 antibody protects against ischemia/reperfusion-impaired myocardial function through modulation of oxidative injuries, inflammation and cardiac remodeling. Antioxidants, 10(2), 1-17. 文章 275. (SCI) 109
  18. Ou, H. C., Chu, P. M., Huang, Y. T., Cheng, H. C., Chou, W. C., Yang, H. L., Chen, H. I., & Tsai, K. L*. (2021, 07 Dec). Low-level laser prevents doxorubicin-induced skeletal muscle atrophy by modulating AMPK/SIRT1/PCG-1α-mediated mitochondrial function, apoptosis and up-regulation of pro-inflammatory responses. Cell and Bioscience, 11(1), 文章 200. (SCI) 110
  19. Ma, C. H., Chou, W. C., Wu, C. H., Jou, I. M., Tu, Y. K., Hsieh, P. L., & Tsai, K. L*. (2021, 10 Dec). Ginsenoside Rg3 attenuates TNF-α-induced damage in chondrocytes through regulating SIRT1-mediated anti-apoptotic and anti-inflammatory mechanisms. Antioxidants, 10(12), 文章 1972. (SCI) 110
  20. Pai, P. Y., Chou, W. C., Chan, S. H., Wu, S. Y., Chen, H. I., Li, C. W., Hsieh, P. L., Chu, P. M., Chen, Y. A., Ou, H. C., & Tsai, K. L*. (2021, 26 Dec). Epigallocatechin Gallate Reduces Homocysteine-Caused Oxidative Damages through Modulation SIRT1/AMPK Pathway in Endothelial Cells. American Journal of Chinese Medicine, 49(1), 113-129. (SCI) 110
  21. Lin, M. Y., Cheng, W. T., Cheng, H. C., Chou, W. C., Chen, H. I., Ou, H. C., & Tsai, K. L*. (2021, 23 Sep). Baicalin enhances chemosensitivity to doxorubicin in breast cancer cells via upregulation of oxidative stress-mediated mitochondria-dependent apoptosis. Antioxidants, 10(10), 文章 1506. (SCI) 110
  22. Chu, P. M., Yu, C. C., Tsai, K. L*., & Hsieh, P. L. (2022, 12 Feb). Regulation of Oxidative Stress by Long Non-Coding RNAs in Vascular Complications of Diabetes. Life, 12(2), 文章 274. (SCI) 110
  23. Chung, W. P., Yang, H. L., Hsu, Y. T., Hung, C. H., Liu, P. Y., Liu, Y. W., Chan, S. H., & Tsai, K. L*. (2022, Mar). Real-time exercise reduces impaired cardiac function in breast cancer patients undergoing chemotherapy: A randomized controlled trial. Annals of Physical and Rehabilitation Medicine, 65(2), 文章 101485. (SCI) 110
  24. Wang, S. H., Tsai, K. L., Chou, W. C., Cheng, H. C., Huang, Y. T., Ou, H. C., & Chang, Y. C. (2022, 04 Jun). Quercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway. American Journal of Chinese Medicine, 50(5), 1281-1298. (SCI) 110
  25. Ma, C. H., Yang, H. L., Huang, Y. T., Wu, Z. X., Cheng, H. C., Chou, W. C., Hung, C. H., & Tsai, K. L*. (2022, 04 May). Effects of percutaneous vertebroplasty on respiratory parameters in patients with osteoporotic vertebral compression fractures. Annals of Medicine, 54(1), 1320-1327. (SCI) 110
  26. Ma, C. H., Wu, C. H., Chiu, Y. C., Tsai, K. L., Jou, I. M., & Tu, Y. K. (2022, 29 Dec). Using External Joint Stabilizer – Elbow (EJS-E) for treating elbow instability—biomechanical assessment and clinical outcomes. BMC Musculoskeletal Disorders, 23(1), 文章 1137. (SCI) 111
  27. Huang, Y. T., Lin, Y. J., Hung, C. H., Cheng, H. C., Yang, H. L., Kuo, Y. L., Chu, P. M., Tsai, Y. F., & Tsai, K. L*. (2022, 09 Aug). The fully engaged inspiratory muscle training reduces postoperative pulmonary complications rate and increased respiratory muscle function in patients with upper abdominal surgery: a randomized controlled trial. Annals of Medicine, 54(1), 2222-2232. (SCI) 111
  28. Chou, W. C., Tsai, K. L., Hsieh, P. L., Wu, C. H., Jou, I. M., Tu, Y. K., & Ma, C. H. (2022, 11 Dec). Galectin-3 facilitates inflammation and apoptosis in chondrocytes through upregulation of the TLR-4-mediated oxidative stress pathway in TC28a2 human chondrocyte cells. Environmental Toxicology, 37(3), 478-488. (SCI) 111
  29. Chiu, Y. C., Wu, C. H., Tsai, K. L., Jou, I. M., Tu, Y. K., & Ma, C. H. (2022, 02 Sep). External Locking Plate Fixation for Femoral Subtrochanteric Fractures. Geriatric Orthopaedic Surgery and Rehabilitation, 13. (SCI) 111
  30. Zhu, G. C., Chen, Y. W., Tsai, K. L., Wang, J. J., Hung, C. H., & Schmid, A. B. (2022, 01 Aug). Effects of Neural Mobilization on Sensory Dysfunction and Peripheral Nerve Degeneration in Rats with Painful Diabetic Neuropathy. Physical therapy, 102(10), 文章 pzac104. (SCI) 111
  31. Hsieh, P. L., Chu, P. M., Cheng, H. C., Huang, Y. T., Chou, W. C., Tsai, K. L*., & Chan, S. H. (2022, 04 Sep). Dapagliflozin Mitigates Doxorubicin-Caused Myocardium Damage by Regulating AKT-Mediated Oxidative Stress, Cardiac Remodeling, and Inflammation. International journal of molecular sciences, 23(17), 文章 10146. (SCI) 111
  32. Hsu, Y. C., Chuang, H. C., Tsai, K. L., Tu, T. Y., Shyong, Y. J., Kuo, C. H., Liu, Y. F., Shih, S. S., & Lin, C. L. (2022, 26 Oct). Administration of N-Acetylcysteine to Regress the Fibrogenic and Proinflammatory Effects of Oxidative Stress in Hypertrophic Ligamentum Flavum Cells. Oxidative Medicine and Cellular Longevity, 2022, 文章 1380353. (SCI) 111
  33. Chiu, Y. C., Wu, C. H., Tsai, K. L., Jou, I. M., Tu, Y. K., & Ma, C. H. (2023, 05 Mar). Using an Internal Joint Stabilizer Through a Single Posterior Approach for Elderly Patients With Terrible Triad Injury. Geriatric Orthopaedic Surgery and Rehabilitation, 14. (SCI) 111
  34. Zhu, G. C., Chen, Y. W., Tsai, K. L., Wang, J. J., Hung, C. H., & Schmid, A. B. (2023, 25 Jul). Swimming exercise attenuates mechanical hypersensitivity and mitigates peripheral nerve degeneration in rats with painful diabetic neuropathy (PDN). Neuroscience Letters, 812, 文章 137406. (SCI) 111
  35. Chiu, T. H., Ku, C. W., Ho, T. J., Tsai, K. L., Hsu, W. C., Chen, Y. A., Ou, H. C., & Chen, H. I. (2023, 29 Jul). Schisanhenol Attenuates OxLDL-Induced Endothelial Dysfunction via an AMPK-Dependent Mechanism. American Journal of Chinese Medicine, 51(6), 1459-1475. (SCI) 111
  36. Chiu, T. H., Ku, C. W., Ho, T. J., Tsai, K. L., Yang, Y. D., Ou, H. C., & Chen, H. I. (2023, 31 Mar). Schisanhenol ameliorates oxLDL-caused endothelial dysfunction by inhibiting LOX-1 signaling. Environmental Toxicology, 38(7), 1589-1596. (SCI) 111
  37. Hsieh, P. L., Tsai, K. L., Chou, W. C., Wu, C. H., Jou, I. M., Tu, Y. K., & Ma, C. H. (2023, 27 Jul). Cisplatin triggers oxidative stress, apoptosis and pro-inflammatory responses by inhibiting the SIRT1-mediated Nrf2 pathway in chondrocytes. Environmental Toxicology, 38(10), 2476-2486. (SCI) 111
  38. Chang, C. C., Tsai, K. L., Cheng, H. C., Chou, W. C., Huang, Y. T., Hsieh, P. L., & Lee, S. D. (2023, 23 Aug). Mangiferin Protects against Angiotensin-II-Enhanced Hypertrophic Markers and Apoptosis in H9c2 Cardiomyocytes. American Journal of Chinese Medicine, 51(7), 1865-1878. (SCI) 112
  39. Chiu, Y. C., Wu, C. H., Tsai, K. L., Jou, I. M., Tu, Y. K., & Ma, C. H. (2024, May). Primary Arthrodesis with Retrograde Hindfoot Nail for Elderly Patients with Tibia Pilon Fractures and Psychiatric Illness. Journal of the American Podiatric Medical Association, 114(3). (SCI) 112
  40. Lee, Y. C., Jou, Y. C., Chou, W. C., Tsai, K. L., Shen, C. H., & Lee, S. D. (2024, 15 Feb). Ellagic acid protects against angiotensin II-induced hypertrophic responses through ROS-mediated MAPK pathway in H9c2 cells. Environmental Toxicology, 39(5), 3253-3263. (SCI) 112

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B. Conference papers
  1. 2008年Society for Heart and Vascular Metabolism國際研究會,第一作者海報發表,美國麻薩諸塞州。Green tea epigallocatechin-3-gallate (EGCG) reduced endothelial cells dysfunction and adhesion molecule expression induced by oxidized-LDL。

  2. 2008年Society for Heart and Vascular Metabolism國際研究會,第二作者海報發表,美國麻薩諸塞州。Ginkgo biloba extract inhibits oxidized LDL-induced cytotoxicity in endothelial cells。

  3. 2008年Society for Heart and Vascular Metabolism國際研究會,第二作者海報發表,美國麻薩諸塞州。Protective effects of solanum lyratum thunb on oxidized LDL-induced cytotoxicity in endothelial cells。

  4. 2009年生物醫學聯合學術年會,第一作者口頭發表,台北。(-)Epigallocatechin-3-gallate (EGCG), a Polyphenolic Compound in Green Tea, Protetcs Against Endothelial Cells Inflammation via Oxidized LDL。

  5. 2009年The American College of Sports Medicine國際研究會,第一作者海報發表,美國華盛頓州。Solanum Lyratum Thumb Prevent Oxidized Low-density Lipoprotein-induced Endothelial Dysfunction。Supported by NSC

  6. 2009年The American College of Sports Medicine國際研究會,第四作者海報發表,美國華盛頓州。Attenuation of inflammation in (-)epigallocatechin-3-gallate(EGCG) -treated endothelial cells via oxidized LDL。

  7. 2010年The Experimental Biology 2010國際研究會,第二作者海報發表,美國加州。EGCG protects against oxLDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling。

  8. 2010年8th Annual Scientific Sessions: Metabolic Signaling in the Cardiovascular System國際研究會,第二作者海報發表,加拿大Inhibitory effect of coenzyme Q10 on endothelial apoptosis induced byoxidized low oxidized low-density lipoprotein via inhibiting ROS/P38MAPK/NF kappaBpathway。

  9. 2011年The Experimental Biology 2011國際研究會,第一作者海報發表,美國華盛頓特區。A novel mechanism of Coenzyme Q10 protects against human endothelial cells from oxidative stress-induced by modulating NO-related pathways。

  10. 2012年Mechanism-Based Natural Product Development Conference,第一作者海報發表,加拿大溫哥華。Ginkgo biloba extract attenuates oxLDL-induced endothelial dysfunction via an AMPK-dependent mechanism。Supported by NSC

  11. 2013年MipTec2013 - The Leading European Event for Drug Discovery,第一作者海報發表,瑞士巴塞爾。Aspirin mitigates Vinorelbine-facilitated endothelial inflammation via modulating SIRT1/LKB1/AMPK mechanism。

  12. Tsai KL, IL-20 enhances hypoxia/reoxygenation-caused oxidative stress and cardiomyocytes dysfunction. i- Pharma. UK2019
  13. Yang, H. L., Chung, W. P., Hung, C. H., & Tsai, K. L. (2021).Effect of Early Exercise Intervention on Physical Fitness in Breast Cancer Patients Receiving Chemotherapy. 物理治療, 46(2), 98-99.

 

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C. Books
  • 蔡昆霖審閱。Tuulia Luomala; Mika Pihlman著。實用筋膜操作指引。2018年。

  • 碩士論文:天然物保護氧化型低密度脂蛋白所誘發內皮細胞損傷之作用機制探討

  • Master dissertation: Protective effects of nature products on oxidized low density lipoprotein induced endothelial cells dysfunction

  • 博士論文:輔?Q10保護氧化型低密度脂蛋白所誘發內皮細胞損傷之作用機制探討

  • PhD dissertation: Protective effects of Co-enzyme Q10 on oxidized LDL-induced endothelial dysfunction

 

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研究計畫 (至少五年內)

國科會計畫

 

計畫名稱

起訖年月

擔任工作

多層面探討慢性中風患者行走速度與任務需求

2019/08/01~2020/07/31

共同主持人

有氧運動合併坐骨神經鬆動術對於糖尿病周邊神經病變之介入成效:從周邊與中樞神經進行探討

2019/08/01~2022/07/31

共同主持人

退化性膝關節炎之加速退化: PKR調控軟骨細胞異常與氧化壓力

2019/08/01~2020/07/31

主持人

高半胱氨酸症對循環系統抗老化基因影響

2018/08/01~2019/07/31

主持人

情境互動於前庭功能低下患者動態評估與訓練之機轉探討

2018/08/01~2019/07/31

共同主持人

坐骨神經鬆動術治療糖尿病造成之神經病理性疼痛的效果及生理機轉(II)

2017/08/01~2018/10/31

共同主持人

運動介入對頭頸癌病人化療造成副作用之效果探討

2017/08/01~2018/07/31

主持人

坐骨神經鬆動術治療糖尿病造成之神經病理性疼痛的效果及生理機轉

2016/08/01~2017/10/31

共同主持人

咖啡綠原酸抗動脈硬化效果之研究

2016/08/01~2017/07/31

主持人

非侵襲性前庭神經刺激對前庭及平衡功能之調控

2016/08/01~2017/07/31

共同主持人

Metformin抗動脈硬化效果之研究:AMPK與SIRT1的角色與運動治療之加成性探討 103-2320-B-006-050-

2014/11/01~2015/10/31

主持人

 

國衛院計畫

 

計畫名稱

起訖年月

擔任工作

探討IL-20 於心肌梗塞的角色

2017/01/01~2020/12/31

主持人

產學計畫

計畫名稱 起訖年月 擔任工作
探討Sirt1活化粒線體生物合成路徑於化療藥物所造成軟骨細胞凋亡與死亡之保護效果 2022/01/01-2022/12/31 主持人
LOX-1接受器訊息路徑於TNF-a造成軟骨細胞凋亡與發炎之角色探討 2021/01/01-2021/12/31 主持人
108年度整合性醫藥衛生科技研究計劃-探討IL-20於心肌梗塞的角色 2019/01/01-2021/12/31 主持人

Galectin-3於TNF-α造成軟骨細胞氧化壓力與發炎之角色探討

 2019/01/01-2019/12/31 主持人

 

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指導學生情況 (至少五年內)
指導學生

  • 104 學年度: 蔡瑋明

  • 105 學年度: 鄭婉廷、鄭惠靖

  • 106 學年度: 楊心綸

  • 106 學年度: 黃郁婷

  • 107 學年度: 吳至翔
    

        

 

參與國際會議

 

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教學與研究國際交流
  • 受聘至國外大學及學術機構講學次數:
  • 至國外學術機構訪問次數:
  • 指導之學生至國外學術機構訪問人次:
  • 指導之學生至國外大學選讀人次:
  • 邀請國外教師至本單位訪問人次:
  • 邀請國外學生至本單位訪問人次:
  • 與國外教師共同主持研究計畫人次:

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